LEON SHARGEL APPLIED BIOPHARMACEUTICS PHARMACOKINETICS PDF

Distribution Tissue permeability of drugs, binding of drugs, apparent, volume of drug distribution, plas- ma and tissue protein binding of drugs, factors affecting protein-drug binding. Kinetics of protein binding, Clinical significance of protein binding of drugs Unit II 07 Hours Elimination: Drug metabolism and basic understanding metabolic pathways renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, Non renal routes of drug excretion of drugs Bioavailability and Bioequivalence:Definition and Objectives of bioavailability, absolute and relative bio- availability, measurement of bioavailability, in-vitro drug dissolution models, in-vitro-in-vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs. Intravenous Injection Bolus b. Intravenous infusion and c Extra vascular administrations. IV bolus Kinetics of multiple dosing, steady state drug levels, calculation of loading and mainetnance doses and their significance in clinical settins.

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JAN DOBRACZYNSKI PDF

Applied Biopharmaceutics & Pharmacokinetics, 7e

The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy. Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them Practical problems and clinical examples with discussions are included in each chapter to help you apply these principles to patient care and drug consultation situations. Chapter Objectives, Chapter Summaries, and Frequently Asked Questions along with additional application questions appear within each chapter to identify and focus on key concepts. Most of the chapters have been revised to reflect our current understanding of drug product performance, bioavailability, bioequivalence, pharmacokinetics, pharmacodynamics, and drug therapy.

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