GATTERMANN KOCH REACTION MECHANISM PDF

In the second step, oxidation of this toluene molecule by potassium permanganate followed by acidic hydrolysis ,produced the expected benzoic acid. There are many other methods for the preparation of benzoic acid from benzene molecule. In the first step, benzene reacts with bromine in presence of iron catalyst , it form bromo benzene. This bromo benzene reacts with metallic magnesium in dry ether medium , changed into Grignard reagent , phenyl magnesium bromide.

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Summary What is Gattermann Reaction? Gattermann reaction is an organic substitution reaction in which we can formylate aromatic compounds. It is named after the German chemist Ludwig Gattermann. Further, this reaction can take place in the presence of Lewis acid catalysts. The Lewis acid catalyst we use mostly is AlCl3.

Then, this method becomes safer as well because zinc cyanide is not that toxic like HCN. Figure Gattermann Aldehyde Synthesis Since the major application of this reaction is to formylate aromatic compounds, we can name it as Gattermann formylation; we sometimes name it as Gattermann salicylaldehyde synthesis. Besides, this reaction is closely similar to Friedel-Craft reactions.

What is Gattermann Koch Reaction? Gattermann Koch reaction is a variation of Gattermann reaction, and this reaction involves the use of carbon monoxide instead of hydrogen cyanide HCN.

Therefore, unlike the Gattermann reaction, we cannot apply Gattermann Koch reaction to phenol and phenol ether substrates. Figure Gattermann Koch Reaction Furthermore, this reaction usually uses zinc chloride as the catalyst, and it requires the presence of a trace amount of copper I chloride as a co-catalyst. Gattermann Koch reaction is a variation of Gattermann reaction. Gattermann Koch reaction is a variation of Gattermann reaction and involves the use of carbon monoxide instead of hydrogen cyanide HCN.

Therefore, the key difference between Gattermann and Gattermann Koch reaction is that Gattermann reaction uses a mixture of hydrogen cyanide and hydrochloric acid, whereas Gattermann Koch reaction uses carbon monoxide instead of hydrogen cyanide. Furthermore, Gattermann Koch reaction usually uses zinc chloride as the catalyst, and it requires the presence of a trace amount of copper I chloride as a co-catalyst. However, in the Gattermann reaction, the catalyst is usually aluminium chloride.

Apart from that, unlike Gattermann reaction, we cannot apply Gattermann Koch reaction to phenol and phenol ether substrates. Below infographic sumarizes the difference between Gattermann and Gattermann Koch reaction. The key difference between Gattermann and Gattermann Koch reaction is that Gattermann reaction uses a mixture of hydrogen cyanide and hydrochloric acid, whereas Gattermann Koch reaction uses carbon monoxide instead of hydrogen cyanide.

Gattermann reaction was named after the German scientist Ludwig Gattermann while Gattermann Koch reaction was named after two the scientists, Julius Koch and Ludwig Gattermann. Reference: 1. Image Courtesy: 1.

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Difference Between Gattermann and Gattermann Koch Reaction

Weitergeleitet von Gattermann-Koch-Synthese Bei der Gattermann-Synthese handelt es sich um eine Namensreaktion in der Organischen Chemie , die verwendet wird, um aromatische Aldehyde aus Phenolen oder anderen Aromaten zu synthetisieren. Benannt wurde sie nach dem Goslarer Chemiker Ludwig Gattermann. Die Gattermann-Synthese kann auch eingesetzt werden, um einzelne Kohlenwasserstoffverbindungen , Heterocyclen wie Furan -, Pyrrol - und Indolderivate sowie Thiophen zu synthetisieren. Mechanismus Bei der Gattermann-Reaktion handelt es sich um eine Elektrophile aromatische Substitution. Dieses wird durch Deprotonierung rearomatisiert. Durch Hydrolyse entsteht der formylierte Aromat.

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Benzene to benzoic acid-Gattermann-Koch reaction

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